HPLC Method Development for Pharmaceutical Analysis

You need to develop an HPLC method to simultaneously quantify aspirin, caffeine, and paracetamol in a tablet formulation. (a) Choose an appropriate column and justify your choice. (b) Design an isocratic or gradient elution method. (c) What detector would you use and why? (d) How would you validate the method according to ICH Q2 guidelines? (e) If the peaks of aspirin and paracetamol overlap, what parameters could you adjust?